The effect of repeated endurance exercise on IL-6 and sIL-6R and their relationship with sensations of fatigue at rest

Research output: Contribution to journalArticle

  • Paula Robson-Ansley
  • Martin Barwood
  • Jane Canavan
  • Susan Hack
  • Clare Eglin
  • Sarah Davey
  • Jennifer Hewitt
  • James Hull
  • Les Ansley
Original languageEnglish
Pages (from-to)111-116
Number of pages6
JournalCytokine
Volume45
Issue number2
DOIs
Publication statusPublished - Feb 2009
Externally publishedYes
Strenuous, prolonged exercise increases interleukin-6 (IL-6) release. The effect of IL-6 is dependent on the availability of IL-6 receptors. Few studies have addressed the impact of exercise on IL-6 receptor levels or procalcitonin (PCT), an indicator of systemic inflammation. Changes in these molecules may give insight into cytokine-related mechanisms underlying exercise-related fatigue. Thirteen trained male subjects partook in the study. They cycled a total distance of 468 km over 6 days. Blood samples were obtained prior to and immediately following Day 1 of the study and then each morning prior to exercise. Blood samples were analysed for plasma IL-6, soluble IL-6 receptor (sIL-6R), C-reactive protein (CRP), PCT, creatine kinase (CK) and cortisol concentrations. Subjects also completed mood state questionnaires each day prior to exercise. IL-6 was elevated immediately post-exercise on Day 1 but was unchanged at rest for the duration of the event. In contrast, sIL-6R, CRP, PCT and CK concentrations were unchanged immediately post-exercise on Day 1 but were significantly elevated at rest over the duration of the event compared with pre-event baseline. sIL-6R was highly correlated to CRP. Cortisol concentrations remained unchanged at all time points. In conclusion, strenuous, prolonged exercise stimulated an acute phase response which was maintained throughout the 6-day event. sIL-6R increase is associated with CRP and may affect subjective sensations of post-exercise fatigue at rest.

    Research areas

  • exercise, fatigue

External organisations

  • University of Portsmouth

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