PTRAMP; a conserved Plasmodium thrombospondin-related apical merozoite protein

Research output: Contribution to journalArticle

  • Joanne Thompson
  • Rachel E. Cooke
  • Sally Moore
  • Laura F. Anderson
  • Chris J. Janse
  • Andrew P. Waters
Original languageEnglish
Pages (from-to)225-232
Number of pages8
JournalMolecular and Biochemical Parasitology
Volume134
Issue number2
Early online date7 Jan 2004
DOIs
Publication statusPublished - Apr 2004
A gene encoding a 352 amino acid protein with a putative signal sequence, transmembrane domain and thrombospondin structural homology repeat was identified in the genome of the human malaria parasite, Plasmodium falciparum and the rodent malaria parasite, Plasmodium berghei. The protein localises in the apical organelles of P. falciparum and P. berghei merozoites within intraerythrocytic schizonts and has, therefore, been termed the Plasmodium thrombospondin-related apical merozoite protein (PTRAMP). PTRAMP co-localises with the Apical Merozoite Antigen-1 (AMA-1) in developing micronemes and subsequently relocates onto the merozoite surface. Although the gene appears to be specific to the Plasmodium genus, orthologues are present in the genomes of all malaria parasite species examined suggesting a conserved function in host-cell invasion. PTRAMP, therefore, has all the features to merit further evaluation as a malaria vaccine candidate.

    Research areas

  • AMA-1, Apical Merozoite Antigen-1, Circumsporozite Protein, CSP, Merozoite, Microneme, P. falciparum thrombospondin-related apical merozoite protein, Plasmodium, PTRAMP, RAP1, Rhoptry Associated Protein, Thrombospondin structural homology repeat, TSR

External organisations

  • Leiden University
  • University of Edinburgh

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