PTRAMP; a conserved Plasmodium thrombospondin-related apical merozoite protein

Joanne Thompson, Rachel E. Cooke, Sally Moore, Laura F. Anderson, Chris J. Janse, Andrew P. Waters

    Research output: Contribution to journalArticlepeer-review

    42 Citations (Scopus)

    Abstract

    A gene encoding a 352 amino acid protein with a putative signal sequence, transmembrane domain and thrombospondin structural homology repeat was identified in the genome of the human malaria parasite, Plasmodium falciparum and the rodent malaria parasite, Plasmodium berghei. The protein localises in the apical organelles of P. falciparum and P. berghei merozoites within intraerythrocytic schizonts and has, therefore, been termed the Plasmodium thrombospondin-related apical merozoite protein (PTRAMP). PTRAMP co-localises with the Apical Merozoite Antigen-1 (AMA-1) in developing micronemes and subsequently relocates onto the merozoite surface. Although the gene appears to be specific to the Plasmodium genus, orthologues are present in the genomes of all malaria parasite species examined suggesting a conserved function in host-cell invasion. PTRAMP, therefore, has all the features to merit further evaluation as a malaria vaccine candidate.
    Original languageEnglish
    Pages (from-to)225-232
    Number of pages8
    JournalMolecular and Biochemical Parasitology
    Volume134
    Issue number2
    Early online date7 Jan 2004
    DOIs
    Publication statusPublished - Apr 2004

    Keywords

    • AMA-1
    • Apical Merozoite Antigen-1
    • Circumsporozite Protein
    • CSP
    • Merozoite
    • Microneme
    • P. falciparum thrombospondin-related apical merozoite protein
    • Plasmodium
    • PTRAMP
    • RAP1
    • Rhoptry Associated Protein
    • Thrombospondin structural homology repeat
    • TSR

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