Projection sites of superficial and deep spinal dorsal horn cells in the nucleus tractus solitarii of the rat

Filomena O. Gamboa-Esteves, Isaura Tavares, Armando Almeida, Trevor F C Batten, Peter N. McWilliam, Deolinda Lima

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

By using anterograde transport of biotin dextran amine injected into the cervical spinal dorsal horn, we have shown that fibres from superficial and deep dorsal horn project to the nucleus tractus solitarii via two distinct pathways. Afferent fibres from the superficial lamina (I-III) were found to course in the dorsal funiculus and terminate bilaterally in the caudal zone of the nucleus tractus solitarii (NTS), mainly within the commissural subnucleus. In contrast, afferents from the deeper dorsal horn laminae (IV-V) were found to course in the dorsolateral fasciculus and terminate ipsilaterally, mostly in the lateral areas of the caudal nucleus tractus solitarii. Similar, but more extensive patterns of labelled fibres were produced by injections into the white matter of the dorsal funiculus and dorsolateral fasciculus, respectively. These observations suggest that the caudal NTS not only serves as a location of visceral afferent convergence and integration, but may also be a receptive area for monosynaptic projections from dorsal horn neurons receiving sensory afferent inputs. Such projections may represent pathways through which NTS neurons are influenced by nociceptive and non-nociceptive information from the dorsal horn and thereby can co-ordinate the appropriate autonomic response, including adjustments in cardiorespiratory reflex output.
Original languageEnglish
Pages (from-to)195-205
Number of pages11
JournalBrain Research
Volume921
Issue number1-2
Early online date9 Oct 2001
DOIs
Publication statusPublished - 7 Dec 2001
Externally publishedYes

Keywords

  • Anterograde transport
  • Biotin dextran amine
  • Medulla oblongata
  • Nucleus of the solitary tract
  • Rat
  • Spinal cord

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