Eysenck's dimensional model of personality includes two indicators of psychological health, defined as neuroticism and psychoticism. In order to examine the association between psychological health and prayer, two samples of sixth-form pupils in Northern Ireland (16- to 18-year-olds) attending Catholic (N = 1246) and Protestant (N = 1060) schools completed the abbreviated Revised Eysenck Personality Questionnaire alongside a simple measure of prayer frequency. The data demonstrated a positive association between prayer frequency and better levels of psychological health as assessed by Eysenck's notion of psychoticism. Among pupils attending both Catholic and Protestant schools, higher levels of prayer were associated with lower psychoticism scores. Among pupils attending Catholic schools, however, higher levels of prayer were also associated with higher neuroticism scores.