Anti-sense peptides that correspond to Amyloid-ß protein residues 1-43 are identified, and are used to identify protein binding sites on enzymes that interact with Amyloid-ß. The anti-sense peptides can be used as, or to identify, therapeutic agents that prevent Amyloid-ß cytotoxicity, and may be useful in the treatment of Alzheimer's disease. The anti-sense peptides show sequence similarity to the protein kinase cdc2, and it has now been found that the cytotoxic form of Aß is phosphorylated.
|A61K 38/00 2006.1,A61K 39/00 2006.1,CO7K 14/47 2006.1
|Published - 10 May 2002