Peptides for use in the treatment of Alzheimer's disease.

Research output: Patent


Anti-sense peptides that correspond to Amyloid-ß protein residues 1-43 are identified, and are used to identify protein binding sites on enzymes that interact with Amyloid-ß. The anti-sense peptides can be used as, or to identify, therapeutic agents that prevent Amyloid-ß cytotoxicity, and may be useful in the treatment of Alzheimer's disease. The anti-sense peptides show sequence similarity to the protein kinase cdc2, and it has now been found that the cytotoxic form of Aß is phosphorylated.
Original languageEnglish
Patent numberWO/2002/036614
IPCA61K 38/00 2006.1,A61K 39/00 2006.1,CO7K 14/47 2006.1
Priority date1/11/00
Filing date1/11/01
Publication statusPublished - 10 May 2002
Externally publishedYes


Dive into the research topics of 'Peptides for use in the treatment of Alzheimer's disease.'. Together they form a unique fingerprint.

Cite this