Peptides for use in the treatment of Alzheimer's disease.

Research output: Patent

Abstract

Anti-sense peptides that correspond to Amyloid-ß protein residues 1-43 are identified, and are used to identify protein binding sites on enzymes that interact with Amyloid-ß. The anti-sense peptides can be used as, or to identify, therapeutic agents that prevent Amyloid-ß cytotoxicity, and may be useful in the treatment of Alzheimer's disease. The anti-sense peptides show sequence similarity to the protein kinase cdc2, and it has now been found that the cytotoxic form of Aß is phosphorylated.
Original languageEnglish
Patent numberWO/2002/036614
Filing date1/11/01
Publication statusPublished - 10 May 2002

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