The present invention is directed to Kissorphin peptides (Tyr-Asn-Trp-Asn-Ser-Phe) and derivatives or analogs thereof that target Amyloid fibril-forming peptides. The Kissorphin peptides are highly specific therapeutic reagents that are useful in detecting, preventing and treating diseases associated with Amyloid fibril-forming peptides, such as Alzheimer's disease, Creutzfeldt-Jakob disease or Diabetes mellitus. According to the invention, a peptide comprises the amino acid sequence defined herein as SEQ ID No. 2, for use in the treatment of a condition associated with Amyloid fibril-forming peptides, wherein the peptide does not directly activate or inhibit the GPR-54 G-protein coupled receptor. Antibodies against Kissorphin peptides and methods for determining whether a subject has, or is predisposed to having, a disorder associated with Amyloid fibril formation are also described.
|IPC||A61K 38/04,A61K 38/07,A61K 38/08,A61K 38/17,A61P 3/10,A61P 25/28,CO7K 5/10,CO7K 14/47,CO7K 16/18|
|Publication status||Published - 2 Jan 2013|