Effect of exercise on postprandial endothelial function in adolescent boys

Matthew J. Sedgwick, John G. Morris, Mary E. Nevill, Keith Tolfrey, Alan Nevill, Laura A. Barrett

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    19 Citations (Scopus)


    The ingestion of high-fat meals induces a state of endothelial dysfunction in adults. This dysfunction is attenuated by prior exercise. The response of young people to these nutritional and physiological stressors has not been established. Thus, the purpose of the present study was to investigate if a bout of moderate-intensity exercise influenced endothelial function (as indicated by flow-mediated dilation (FMD)) following the ingestion of a high-fat breakfast and lunch in adolescent boys (aged 12·6-14·3 years). Two, 2 d main trials (control and exercise) were completed by thirteen adolescent boys in a counter-balanced, cross-over design. Participants were inactive on day 1 of the control trial, but completed 60Â min of walking at 60Â % peak oxygen uptake in the exercise trial. On day 2, endothelial function was assessed via FMD prior to, and following, ingestion of a high-fat breakfast and lunch. There was no difference in fasting FMD between the control and exercise trial (P=Â 0·449). In the control trial, FMD was reduced by 32Â % following consumption of the high-fat breakfast and by 24Â % following lunch. In the exercise trial, the corresponding reductions were 6 and 10Â %, respectively (main effect trial, P=Â 0·002). These results demonstrate that moderate-intensity exercise can attenuate the decline in FMD seen following the consumption of high-fat meals in adolescent boys.

    Original languageEnglish
    Pages (from-to)301-309
    Number of pages9
    JournalBritish Journal of Nutrition
    Issue number2
    Publication statusPublished - 28 Jul 2013


    • CHD risk
    • Flow-mediated dilation
    • Postprandial lipaemia
    • TAG


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