Effect of acute hypoxia on cognition: A systematic review and meta-regression analysis

Terry McMorris, Beverley Hale, Martin Barwood, Joseph Costello, Jo Corbett

    Research output: Contribution to journalArticlepeer-review

    147 Citations (Scopus)
    141 Downloads (Pure)


    A systematic meta-regression analysis of the effects of acute hypoxia on the performance of central executive and non-executive tasks, and the effects of the moderating variables, arterial partial pressure of oxygen (PaO2) and hypobaric versus normobaric hypoxia, was undertaken. Studies were included if they were performed on healthy humans; within-subject design was used; data were reported giving the PaO2 or that allowed the PaO2 to be estimated (e.g. arterial oxygen saturation and/or altitude); and the duration of being in a hypoxic state prior to cognitive testing was ≤6 days. Twenty-two experiments met the criteria for inclusion and demonstrated a moderate, negative mean effect size (g = −0.49, 95% CI −0.64 to −0.34, p < 0.001). There were no significant differences between central executive and non-executive, perception/attention and short-term memory, tasks. Low (35–60 mmHg) PaO2 was the key predictor of cognitive performance (R2 = 0.45, p < 0.001) and this was independent of whether the exposure was in hypobaric hypoxic or normobaric hypoxic conditions.
    Original languageEnglish
    Pages (from-to)225-232
    JournalNeuroscience & Biobehavioral Reviews
    Issue numberMarch
    Early online date17 Jan 2017
    Publication statusPublished - 1 Mar 2017


    • Arterial partial pressure of oxygen
    • normobaric
    • hypobaric
    • central executive
    • perception
    • short-term memory
    • regional cerebral blood flow
    • catecholamine
    • glossypharyngeal nerve
    • carotid body
    • internal carotid arteries
    • vertebral arteries


    Dive into the research topics of 'Effect of acute hypoxia on cognition: A systematic review and meta-regression analysis'. Together they form a unique fingerprint.

    Cite this