The purpose of this special issue of Mental Health, Religion and Culture was to provide a forum for examples of current research examining work-related psychological health, stress, and burnout among clergy. This collection, comprising six empirical articles and five book reviews, is drawn from researchers in Australia, the UK, and the US. Of the six empirical papers, three studies employed the Maslach Burnout Inventory among samples of clergy in Australia (Miner, 2007a, 2007b) and the US (Doolittle, 2007), while the remaining three studies employed a modified form of the Maslach Burnout Inventory (Rutledge & Francis, 2004) especially adapted for use among clergy in the UK (Francis, Turton, & Louden, 2007; Randall, 2007; Turton & Francis, 2007). Consistent findings across all six studies indicated a high level of work-related burnout among the samples of clergy, irrespective of religious denomination or country. In combination, this work demonstrated the wide range of matters currently being investigated by researchers as well as the variety of methodologies being employed within the social scientific study of religion and related disciplines focused on clergy work-related psychological health, stress, and burnout.