Cholesterol in Alzheimer's disease and other amyloidogenic disorders

J. Robin Harris, Nathaniel G.N. Milton

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

35 Citations (Scopus)

Abstract

The complex association of cholesterol metabolism and Alzheimer’s disease is presented in depth, including the possible benefits to be gained from cholesterol-lowering statin therapy. Then follows a survey of the role of neuronal membrane cholesterol in Aβ pore formation and Aβ fibrillogenesis, together with the link with membrane raft domains and gangliosides. The contribution of structural studies to Aβ fibrillogenesis, using TEM and AFM, is given some emphasis. The role of apolipoprotein E and its isoforms, in particular ApoE4, in cholesterol and Aβ binding is presented, in relation to genetic risk factors for Alzheimer’s disease. Increasing evidence suggests that cholesterol oxidation products are of importance in generation of Alzheimer's disease, possibly induced by Aβ-produced hydrogen peroxide. The body of evidence for a link between cholesterol in atherosclerosis and Alzheimer's disease is increasing, along with an associated inflammatory response. The possible role of cholesterol in tau fibrillization, tauopathies and in some other non-Aβ amyloidogenic disorders is surveyed.

Original languageEnglish
Title of host publicationCholesterol Binding and Cholesterol Transport Proteins:. (Subcellular Biochemistry vol 51)
EditorsJ. Robin Harris
Place of PublicationDordrecht
PublisherSpringer
Pages47-75
Number of pages29
Volume51
ISBN (Electronic)9789048186228
DOIs
Publication statusPublished - 1 Jan 2010
Externally publishedYes

Publication series

NameSub-Cellular Biochemistry
PublisherPlenum Publishers
ISSN (Print)0306-0225

Keywords

  • Alzheimer's
  • Amyloid-P
  • Ap
  • Cholesterol
  • Disease
  • Fibrillogenesis
  • HMG-CoA reductase inhibitor
  • Oligomerization
  • Statin

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