Anandamide and noladin ether prevent neurotoxicity of the human amyloid-β peptide

Research output: Contribution to journalArticlepeer-review

108 Citations (Scopus)

Abstract

Cannabinoid receptor agonists including anandamide and noladin either have recently been suggested to exhibit neuroprotective properties. The amyloid-β (Aβ) peptide is thought to be responsible for the neurodegenerative changes associated with Alzheimer's disease pathology. This study characterizes the effects of anandamide and noladin ether on the neurotoxicity of Aβ in differentiated human teratocarcinoma cell line, Ntera 2/cl-D1 neurons. Anandamide and noladin ether, at nanomolar concentrations, showed concentration dependent inhibition of Aβ toxicity. A CB1 cannabinoid receptor antagonist, AM251, prevented the protective effects of anandamide and noladin ether. The mitogen activated protein kinase (MAPK) pathway inhibitor PD98059 also prevented the protective effects of cannabinoids and corticotrophin-releasing hormone. These results suggest that activation of the MAPK pathway by either cannabinoids or corticotrophin-releasing hormone could be used to prevent Aβ peptide induced neurodegeneration.

Original languageEnglish
Pages (from-to)127-130
Number of pages4
JournalNeuroscience Letters
Volume332
Issue number2
DOIs
Publication statusPublished - 31 Oct 2002
Externally publishedYes

Keywords

  • Alzheimer's
  • Amyloid-β
  • Anandamide
  • Cannabinoid
  • Corticotrophin-releasing hormone
  • Mitogen activated protein kinase
  • Neurons
  • Noladin ether

Fingerprint

Dive into the research topics of 'Anandamide and noladin ether prevent neurotoxicity of the human amyloid-β peptide'. Together they form a unique fingerprint.

Cite this