Amyloid-β binds catalase with high affinity and inhibits hydrogen peroxide breakdown

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Abstract

Amyloid-β (Aβ) specifically bound purified catalase with high affinity and inhibited catalase breakdown of H2O2. The Aβ-induced catalase inhibition involved formation of the inactive catalase Compound II and was reversible. Catalase⇆Aβ interactions provide rapid functional assays for the cytotoxic domain of Aβ and suggest a mechanism for some of the observed actions of Aβ plus catalase in vitro.

Original languageEnglish
Pages (from-to)293-296
Number of pages4
JournalBiochemical Journal
Volume344
Issue number2
DOIs
Publication statusPublished - Dec 1999
Externally publishedYes

Keywords

  • Alzheimer's
  • Antibodies
  • Cytotoxicity
  • Myeloma
  • Peroxidase

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